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南美蟛蜞菊中二萜化学成分的定性与定量分析研究
贾永霞,谭建文
1. 中国科学院华南植物园, 中国科学院植物资源保护与可持续利用重点实验室,1. 中国科学院华南植物园, 中国科学院植物资源保护与可持续利用重点实验室
摘要:  为了解南美蟛蜞菊[Sphagneticola trilobata (L.) Pruski]植物的化学成分,从其全株乙醇提取物中分离得到8个二萜类化合物。经光谱分析,分别鉴定为ent-16β,17-dihydroxy-9(11)-kauren-19-oic acid (1)、cussovantonin B (2)、ent-16-kauren-19-oic acid(3)、ent-3β-hydroxy-16-kauren-19-oic acid (4)、16α-hydroxy-ent-kauran-19-oic acid (5)、2β,16α-dihydroxy-ent-kauran-19-oic acid (6)、3α-angeloyloxypterokaurene L3 (7)和pterokaurene L3 (8)。化合物4为首次从蟛蜞菊属植物中分离获得,化合物126为首次从南美蟛蜞菊中分离得到。化合物3具有显著的抗菌活性和显著抑制α-葡萄糖苷酶活性。采用五氟苄溴进行底物五氟苄基衍生化并结合GC-MS 分析表明,化合物3在南美蟛蜞菊茎和叶中的含量分别为(1.00±0.21) mg g-1 FW和(0.78±0.04) mg g-1 FW。
关键词:  南美蟛蜞菊  二萜化合物  抗菌  α-葡萄糖苷酶抑制剂  定量分析
DOI:10.11926/j.issn.1005-3395.2015.06.016
分类号:
基金项目:国家自然科学基金项目(31270406);广东省自然科学基金项目(2014A030313742);中国科学院仪器功能开发项目(YG2012050)资助
Qualitative and Quantitative Analysis of Diterpenoid Compounds in Sphagneticola trilobata (L.) Pruski
JIA Yong-xia and TAN Jian-wen
1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, China; 2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China,1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, China; 2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China
Abstract:  In order to understand the chemical constituents of Sphagneticola trilobata (L.) Pruski, eight diterpenoids were isolated from the ethanol extract of its whole plants. On the basis of spectral data, they were identified as ent-16β,17-dihydroxy-9(11)-kauren-19-oic acid (1), cussovantonin B (2), ent-16-kauren-19-oic acid (3), ent-3β-hydroxy-16-kauren-19-oic acid (4), 16α-hydroxy-ent-kauran-19-oic acid (5), 2β,16α-dihydroxy-ent-kauran-19-oic acid (6), 3α-angeloyloxypterokaurene L3 (7) and pterokaurene L3 (8). Compound 4 were isolated from genus Sphagneticola for the first time, and compounds 1, 2 and 6 were isolated from S. trilobata for the first time. Compound 3 showed strong antibacterial activity against several bacteria and further inhibited significantly α-glucosidase activity in vitro. Based on structural derivation with pentafluorobenzyl bromide coupled with GCMS techniques, the contents of compound 3 in the stem and leaves of S. trilobata were (1.00±0.21)mg g-1 FW and (0.78±0.04) mg g-1 FW, respectively.
Key words:  Sphagneticola trilobata  Diterpenoids  Antibacterial  α-Glucosidase inhibitor  Quantitative analysis

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